It starts from Deptford Broadway at traffic lights on the A2 and A2209 and heads south along Brookmill Road, reflecting its closeness to the River Ravensbourne. Soon afterwards we pass Brookmill Park on our left with the River Ravensbourne on the other side and the Docklands Light Railway Lewisham branch just on the far side of the railway. On our right is the uniquely named Friendly Street which leads to Friendly Park. A little further on we pass the remains of a railway embankment, part of which is within Brookmill Park. This carried the railway between Nunhead and Greenwich Park and closed as early as 1917; there was an arched bridge over Brookmill Road here until the late 1960s/early 1970s. This is the point where the traffic usually tails back from the congestion in Lewisham.
Brookmill Road becomes Thurston Road and we pass under two railway bridges that are at different heights. The first bridge carries the railway between Charing Cross and Cannon Street to Lewisham and the second bridge carries the St Johns Flyover and the railway between Nunhead and Lewisham. On our right is the retaining wall for the main line from Charing Cross to the Kent Coast and Hastings. We pass the Thurston Industrial Estate and a retail park and there is a small travellers encampment on our left. Thurston Road becomes one-way for traffic going towards Lewisham; traffic going towards Deptford must use Jerrard Street. Both branches of the A2210 finish on the A20 Loampit Vale - inbound at traffic lights, outbound at a T-junction. The A21 starts at a roundabout just to the left.