The A5181 is a short link road into Trafford Park from the south.
Just north of M60J7 it leaves the A56 at a roundabout signed Urmston. It heads north along the weight-restricted Barton Road into Stretford and meets the A5145 and B5213 at traffic lights. There's a short section of D2 - unexpected, as this is a residential road, after which the road reverts to S2 and soon goes under the Manchester to Warrington railway line. We then reach the Kellogg's factory, where its overbridge welcomes us to Trafford Park. On the far side there's an unprotected level crossing on the Trafford Park Railway and a set of traffic lights where the B5211 turns left.
We continue north over the Bridgewater Canal and follow Mosley Road through Trafford Park. There's a set of traffic lights serving the D2 Westinghouse Road, which is unclassified but a main artery through the estate. Several industrial buildings and warehouses later we reach a signalised crossroads on the A5081, where the road ends.