The B6105 crosses the hills to the north of the Derbyshire town of Glossop.
It starts at a crossroads in the town centre on the A57 and A624. The road heads north past the station, climbing as it does so. The road reaches open country and continues to climb onto the moors. At the summit it finally enters the Peak District National Park, whose boundary detours specifically to place Glossop outside.
The road now skirts the southern edge of Longdendale. This contains several reservoirs which can be seen below. Eventually we will drop down to their level but the B6105 seems in no hurry to do so. It detours sharply to the right, known as the Devil's Elbow, to cross a steep valley, before continuing eastwards, descending gently. After crossing the Pennine Way, near the bottom of its first major descent since it started at Edale the road zigzags across the former Woodhead railway line and skirts the southern edge of Torside Reservoir.
Eventually the B6105 bends sharply to the left, by the drive to the long-gone Crowden station, and crossed the dam of Woodhead Reservoir. It reaches the A628 albeit considerably below the level of that road; there is a flight of steps for pedestrians. The B6105 bears right and runs parallel to the A628 for a short distance until the two roads reach the same level. The B6105 then ends at a sharply angled T-junction on the A628.