The A2208 is a short A-road in the east of the London Borough of Southwark.
It starts on the A2 Old Kent Road and heads roughly northeast along Rotherhithe New Road. About halfway, it goes under a pedestrian footbridge (which replaced a disused railway bridge) then through a tunnel under the railway line east of London Bridge station, meeting the A2206 immediately after. Round the corner it reaches a roundabout where it splits. Although both branches are two-way, it is preferable for outbound traffic to go along the northern branch (Hawkestone Road) and inbound traffic along the southern, original branch (the continuation of Rotherhithe New Road). Both branches end on the A200.