The A2220 follows the old A264 on its east-west route through the New Town of Crawley.
The road starts at a roundabout on the edge of Copthorne where the A264 leaves its original route to head for the M23. The A2220 heads southwest along Copthorne Road, entering open country almost immediately, although there is a short section following where large houses are set back from the road. After crossing the M23 the Crawley urban area is met; typically for a New Town radial road we pass between rather than through housing estates.
The B2036 is crossed at a roundabout that predates the expansion of the town this far east. The road continues on with a number of side streets giving access to the residential areas. The road soon becomes dual-carriageway and goes under a railway bridge passing under Three Bridges station, whose entrance is on the far side. The road narrows as it reaches out-of-town light industry and then passes a playing field before reaching a gyratory with a hotel in the middle. Westbound traffic must go round three sides to continue along its route. Incidentally, we have currently left the old line of the A264, which ran on the far side of the playing field.
We rejoin the old road at a roundabout in a retail park, then a short dualled section takes us into the town centre and traffic lights on the A2004. We zigzag across this, turning left then right at the next set of lights to follow the inner ring road. The A2219 (former A23) is met at a gyratory and we continue in a multiplex along that road as far as the next roundabout, where it continues along the inner ring road whilst we bear left to leave town.
We soon TOTSO left and now head southwards along Horsham Road. We cross a level crossing and continue through the suburbs to a roundabout where we cross the A23 western bypass. The road now becomes D2 and we follow a radial route across a number of large roundabouts. The central reservation, especially either side of the roundabouts, is suspiciously wide, suggesting grade-separation was once planned. We soon reach the edge of town and a further roundabout where we end, back on the A264.