The A4501 is a short link road to the east of Northampton town centre. The road is out-of-zone but presumably gained its number owing to its proximity to the A4500 on which it starts.
The route starts at traffic lights on the A4500 Wellingborough Road and heads south along the residential St Edmund's Street. There's a set of traffic lights where we cross the unclassified Billing Road and we continue on to Cliftonville Road. We pass the hospital and a few office blocks and descend past a couple of car dealerships to traffic lights on the A428 where the road ends.