Eaglesfield Interchange is a standard full-access dumbbell junction on the A74(M), linking the motorway to the B722, which then connects to the B7076. The current junction opened in November 1995 with the construction of the motorway.
Until 1995 a diamond junction existed a little to the north of the location of the current junction, linking the B722 to the A74 dual carriageway which had opened in 1967. In 1995 when the motorway was built, the A74 was downgraded to B7076 and was made a single carriageway. However, the overbridge carrying the B722 over the old A74 still exists and the former southbound off-slip has been realigned to meet each road at right angles to provide a connection between the B722 and the current B7076.
Before that, however, when the A74 was just an ordinary single carriageway, it met the B722 at the southern end of the village of Eaglesham, roughly where the B7076 now crosses the railway line. Indeed, old OS maps suggest that the crossroads was sited directly above the railway. The old line of the B722 can still be seen, chopped up by each improvement to the A74 and A74(M).