The Raith Interchange was opened in 1968 as junction 5 on the M74. When the junction numbering was reversed in 1986 (see M74 and A74(M) History) each junction n became 10-n, so Raith's number remained the same.
It originally served the A725 to the east and the B7012 to the west. As East Kilbride grew, the B7012 was consumed into the A725.
A third layer has been added to the junction by putting the A725 in a cutting under both the roundabout and the M74 mainline, realigning the west side of the roundabout westward and abolishing the smaller at-grade roundabout which was adjacent to the south-west.