The A5208 is a short link road joining Kirkby to the A580 East Lancashire Road. It is dual-carriageway for its entire length.
The road starts at traffic lights to the east of Kirkby town centre, where the southbound A506 TOTSOs to the right. We continue southeastward along the residential County Road, with the occasional side street. Soon, however, the houses disappear on the left to be replaced by Knowsley Industrial Park. There are two roundabouts serving this and we meet the A5207, which takes us to the M57, at the second.
We continue along South Boundary Road through the industrial estate and bear right at the next roundabout to head south on Coopers Lane. The road ends shortly afterwards at a signalised crossroads on the A580. The unclassified road ahead soon meets the B5202; traffic from that road wanting to head east along the A580 must use this crossroads.