|Distance:||113.7 km (70.7 miles)|
|Meets:||N21, N70, N23, R561, N72, R876, R570, R569, R582, R618, R584, R590, R585, R619, R608, N40, R579, R641, R846, R608, R847, R848, N8, N20|
Since completion of the Tralee bypass in August 2013, the route has begun south of Tralee at the Camp Roundabout, end-point too of the N21 and N70. Before that date the N22 had started three kilometres further east at the John Cronin Roundabout. The two kilometres of the old route from there to Bealagrellach, where the new alignment comes in on the right, is now the L2057.
From Bealagrellach the N22 first heads southeastward towards Kerry Airport, where it meets the N23. There's then a rather slow and winding route southwards to Killarney, where the N22 meets the N71 and N72, the latter of which it briefly multiplexes with. There's a single carriageway bypass of Killarney to the north, after which it's back onto the original road, where the N72 heads left towards Mallow and the interior of County Cork.
Meanwhile, the N22 heads around the Cork and Kerry mountains, finding its way through valleys and over the boundary into County Cork, up to Macroom. It then crosses the River Lee, the south side of which it follows into Cork. The road quality improves after Cookstown, and just before Ballincollig it widens to grade-separated dual carriageway at the Ballincollig bypass (2004), and also form the western end of the Cork Southern Ring.
There's a TOTSO at the next roundabout with straight on being the N40, as the N22 turns back towards the Lee and the centre of Cork. It ends at the docks with the N8 and N20 in a confusing mish-mash of signs.