The B481 is a rural B-road in south Oxfordshire.
It starts at traffic lights on the A4155 in Caversham, a suburb of Reading. It heads north out of town and through Sonning Common before climbing the steep and winding Peppard Hill to Rotherfield Peppard.
After a few more miles of scattered woodland and housing the road reaches Nettlebed. There is a roundabout on the eastern edge of the village where the B481 meets the A4130, after which there is a short multiplex west into the village.
Up until the 1960s, none of the description above was part of the B481. This section was numbered A4009 in 1922 and only became part of the B481 later on. The original southern end of the B481 was here in Nettlebed. After going across the Green the B481 turns right to regain its number and continues north. It goes through no more places of note and eventually ends at a TOTSO on the B480 on the far side of Cookley Green. Interestingly signage suggests that the southern end of the B480 is unsuitable for through traffic and so all traffic between the A4130 and Watlington (the next village north on the B480) is directed along the B481.