The B5356 follows the M56 to the south of Warrington. The road was originally unclassified but gained its number in the late 1920s.
The road starts on the A56 Daresbury bypass. It briefly follows that road's old route into the village then TOTSOs left to pass All Saints' Church, where Lewis Carroll's father was curate. We now leave Daresbury and cross the open fields into Hatton, where we TOTSO right at a T-junction. After zigzagging through the village we bear left to avoid crossing the M56 then carry on into Stretton. Here we meet the A49 at traffic lights.
The A-road is crossed at a staggered crossroads, with a single set of lights covering the entire junction, after which we continue northeastwards. Although we continue across fields the road never becomes wholly rural. Presently we meet a roundabout from where an unclassified road bears left to serve an unbuilt development, after which we enter Appleton Thorn and run through the village centre, then reach a T-junction on the far side.
We TOTSO left and quickly reach a roundabout where we turn right. This is a modern road built to improve access to an industrial estate just to the south; the original B5356 followed Cartridge Lane, which is now almost unused despite still being a through route, just to the north. Old and new roads meet just before journey's end at a roundabout on the A50 just west of M6J20.