The B722 is a cross-country B-road in eastern Dumfriesshire.
It starts at traffic lights on the B721 (former A75) in the centre of Annan. It heads north out of town and forms the boundary of the urban area for most of the distance to the A75 Annan bypass, which is crossed at a bridge without a junction. The road then continues north across the fields before starting to turn easterly.
The road passes to the north of the former RAF Annan, which later became the site of the landmark Chapelcross Nuclear Power Station, which has also now closed. After running under a low hill the road bends sharply to the left and continues north to reach the dumbbell A74(M)J20, with the B-road going over the motorway. Just beyond, the road goes over the B7076. Before the motorway was built this road was the A74, which was accessed via a diamond GSJ still obvious from aerial photography. There is now, however, only one slip road left (which is itself not one of the originals) just after the bridge which connects the B722 and the B7076. Incidentally, before the A74 was dualled, the two roads crossed at a simple crossroads on top of the railway bridge just to the east.
The B722 goes over the West Coast Main Line before running through the long village of Eaglesfield. It then continues north and climbs over a hill before descending again to Waterbeck where it bends to the right on meeting the B725. The road continues northeastwards for another couple of miles across undulating terrain, essentially following the valley of the Kirtle Water, before ending at a T-junction on the B7068 (former A709).