|Location Map ( geo)|
|Distance:||2.8 miles (4.5 km)|
|Met (1923):||A6, A5067, A57, A5068, B5222, A56, A6|
|Now part of:||A5184, A34, A6010|
|Route outline (key)|
It started on the A6 in Longsight, to the southeast of Manchester city centre, then followed Plymouth Grove and Upper Brook Street, Princess Street, John Dalton Street and Bridge Street, before ending once again on the A6 just after Salford Central railway station.
Around the 1935 Road numbering revision it gained an eastern extension along Kirkmanshulme Lane as far as the B5220 Northmoor Road. Then in the 1960s the entire A34 was moved one block east, taking over the whole of the B5221 north of Plymouth Grove. The remainder was also upgraded to Class I status round the same time, making the B5221 number redundant.